Ovagen

Ovagen is a liver-derived peptide bioregulator developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology. It is extracted from bovine liver tissue and proposed to support hepatocyte function, liver structural integrity, and protection against hepatotoxic injury. The pentapeptide form Ile-Glu-Pro-Gly-Pro is the most commonly cited sequence, though alternative shorter sequences appear in some vendor and review sources — the sequence field above reflects the predominant published form.

Ovagen belongs to the Khavinson-class bioregulator peptides proposed to modulate hepatocyte gene expression through peptide-DNA or peptide-chromatin interactions. In liver injury models, the proposed mechanism involves: - Restoration of hepatocyte antioxidant defense gene expression (superoxide dismutase, catalase pathways) - Reduction of inflammatory gene activation in hepatic stellate cells and Kupffer cells - Support of hepatocyte protein synthesis capacity - Promotion of structural repair in damaged liver parenchyma

The mechanistic characterization is limited to the level of histological and functional outcomes in animal models; the specific gene targets and molecular interactions have not been characterized by the methods (chromatin immunoprecipitation, RNA-seq) that would confirm the proposed DNA-binding mechanism.